UChicago Medicine River East building

355 E. Grand Ave.

Chicago, IL 60611


Located in Chicago’s Streeterville neighborhood, UChicago Medicine River East is a state-of-the-art outpatient center featuring a wide range of care services:

  • Primary care, including wellness exams, diagnosis and treatment of common conditions and some urgent concerns, such as infections and sprains
  • Specialty care from more than 25 specialty areas, including cancer care, cardiology and cardiac surgery, dermatology, gastroenterology, obstetrics and gynecology, otolaryngology, comprehensive weight management and more
  • Cancer screenings, including mammography, colonoscopy and skin cancer screening
  • Infusion therapy
  • Lab testing services

Easy Check-In

The River East location is designed to streamline visits with user-friendly kiosks for check-in and payments as well as work desks complete with charging outlets throughout the waiting area. Mobile check-in is offered on the MyChart app, and push notifications can be sent if earlier appointments open up.

Skip the Line at Your Next Visit with eCheck-In and Hello Patient

Verify medical and insurance information, pay visit co-pays in advance, notify the care team when you've arrived and more with eCheck-In and Hello Patient, available through the MyChart app.

Learn more about eCheck-In and Hello Patient by viewing our step-by-step instruction guide (PDF).


Request an appointment at UChicago Medicine River East

Request an Appointment or call 888-824-0200

Woman holding "Get your flu shot" chalkboard sign

Protect Yourself and Others from the Flu

UChicago Medicine offers flu shots for adults and children at several downtown, South Side and south suburban locations. Find a flu vaccination clinic near you.

Flu Vaccination Clinics

Directions and Parking

Our pedestrian entrance is located at 355 E. Grand Ave. (corner of Grand Ave and McClurg Ct.). Please take the elevator or stairs to the second floor.

For primary care patients, please enter the building through the 339 E. Grand Ave. entrance.

From Lake Shore Drive: Exit at Grand Ave. and proceed west towards McClurg Ct.  An entrance to the parking garage is located past that intersection on your left at 321 E. Grand.

From the West: Take Illinois St. east towards Columbus Dr. An entrance to the parking garage is located past that intersection on your left at 300 E. Illinois. 

Once inside the parking garage, follow the signs to LL3 (Fall) for designated UChicago Medicine patient parking.

Take the Red Line to Grand Ave. Walk east 0.5 miles on Grand to McClurg Ct., or take the 29 Navy Pier bus from Illinois & State to McClurg Ct. Walk north one block to 355 E. Grand Ave. Please take the elevator or stairs to the second floor.
We offer discounted parking in the Standard Parking that can be entered through either 300 E. Illinois or 321 E. Grand. Our discounted parking rate is $12 for 4 hours.

Hours of Operation

Monday 8:00AM - 5:00PM
Tuesday 8:00AM - 8:00PM
Wednesday 8:00AM - 8:00PM
Thursday 8:00AM - 8:00PM
Friday 8:00AM - 5:00PM
Saturday 8:00AM - 12:00PM
2nd and 4th Saturdays of the month

Monday 8:00AM - 5:00PM
Tuesday 8:00AM - 5:00PM
Wednesday 8:00AM - 5:00PM
Thursday 8:00AM - 5:00PM
Friday 8:00AM - 5:00PM
Saturday CLOSED

UChicago Medicine River East

Request an Appointment

The information you provide will enable us to assist you as efficiently as possible. A representative will contact you within one to two business days to help you schedule an appointment.
Please note this electronic request form is not for same- or next-day appointments. If you prefer to speak to someone directly, please call 1-888-824-0200. If you have symptoms of an urgent nature, please call your doctor or go to the emergency room immediately.

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